How are Dr. Jekyll and Victor Frankenstein lonely and isolated men?

Both Henry Jekyll and Victor Frankenstein are obsessed with scientific ideas/experiments that go against the ethics of society.  They are forced to practice in secret, not even sharing their outlandish (and what some may call heretical) ideas with their closest frieinds or relatives.  Henry Jekyll creates a potion that allows him to disguise himself from society (as Edward Hyde) and to do all of the unspeakable acts he secretly desires while still maintaining his respectable reputation as a doctor.  When the experiment gets out of control, and Henry Jekyll can  no longer "conjure" Edward Hyde at will because Hyde's personality emerges unexpectedly, Jekyll is forced to isolate himself.  In Frankenstein, Victor Frankenstein tries to play God in bringing life to dead flesh.  When he succeeds in doing so, he immediately abandons the creature in disgust; however, who can he tell about it?  No one!  So he keeps his secret to himself, and that knowedge eats away at him, especially when the creature begins to kill Victor's family.  In these ways, both Henry Jekyll and Victor Frankenstein become lonely, isolated men.