Lady Macbeth's words reflect the workings of her conscience, which is driving her to madness. She can no longer hide her guilt and cannot help revealing her crime to those around her.
The references to the blood hark back to the murder of Duncan. She had said (Act II/2) "A little water clears us of this deed," but now no quantity is enough. She had used blood to incriminate the innocent grooms,
If he do bleed,
I'll gild the faces of the grooms withal,
For it must seem their guilt.
and now it follows her, impossible to remove.
Remarks that scold Macbeth for his timidness, such as "A soldier, and afeared?" and "No more o' that" again evoke the scene before and after Duncan's murder, where Lady Macbeth treated all of Macbeth's doubts with utter contempt:
Why, worthy thane,
You do unbend your noble strength to think
So brainsickly of things.
The memory now haunts her, since as she probably realizes, without her urging Macbeth may well have shrunk away from committing the murder.
"The Thane of Fife had a wife; where is she now?" show that Lady Macbeth is also haunted by the less direct consequences of her actions. Macduff was Thane of Fife, and Macbeth had had his wife and family murdered in his rage at the witches' second set of predictions (Act IV/1, 2).
Finally, "Hell is murky" indicates Lady Macbeth feels she is damned, something that had also occured to her husband, though he had set it aside (Act I/7)
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